Defend Patients, Defeat Cancer

Radioligand therapy has already changed the treatment of neuroendocrine tumors and of prostate cancer. Extending it to other solid tumors requires new targets, ligands that bind them selectively, and the manufacturing and supply chain needed to deliver a radioactive drug to a patient on schedule. Aurelius was founded to do all three.

No longer talk at all about the kind of man that a good man ought to be, but be such.
Marcus Aurelius, Meditations, X.16

Where We Come From

The people who lead Aurelius have, between them, taken radiopharmaceuticals from first synthesis through lead optimization, GMP manufacturing, regulatory submission, and commercial supply, on programs that are now in the clinic or on the market. That experience covers each stage a radioligand has to pass, and the company was built so that no stage is being done for the first time.

Discovery
Radiotracers that went from a first synthesis in an academic laboratory to first-in-human imaging, and on to programs now run by global pharmaceutical companies.
Optimization
Lead optimization of peptide and small-molecule radioligands for affinity, residence time, and clearance, through to the selection of clinical candidates.
CMC
Process, analytical, and regulatory development of radiopharmaceuticals, from first-in-human clinical batches to large-scale commercial distribution, and the transfer of those processes to international manufacturing sites.
Commercial
Manufacturing and supply of approved radiopharmaceuticals, where a short-lived product has to reach the clinic on schedule every day.
Record

Each stage a radioligand has to pass has been passed before by someone on this team.

Leadership

John Carney
Chief Executive Officer

Experience in licensing and partnering radiopharmaceutical programs, including the transfer of a clinical-stage program to a global pharmaceutical company.

Giacomo Pirovano
Giacomo Pirovano
Chief Scientific Officer

Radiochemist. Previously at Memorial Sloan Kettering Cancer Center, Evergreen Theragnostics, and Lantheus.

William Miller
William Miller
Vice President, Head of CMC

Radiochemist. Process, analytical, and regulatory development of radiopharmaceuticals from the first clinical batch to Module 3. Previously at Alpha-9 Oncology, Lantheus, the University of Virginia, and the National Institutes of Health.

Sangram Kale
Sangram Kale
Vice President, Head of Discovery

Peptide chemist. Previously at Biosynth.

Thomas Lindner
Thomas Lindner
Vice President, Head of Radiochemistry

Radiochemist. Developed radiotracers at Heidelberg University Hospital that went from first synthesis to first-in-human imaging and on to global clinical programs. Previously at Evergreen Theragnostics and Lantheus.

Alexandra Arranja
Alexandra Arranja
Director, Preclinical

Formulation and process scientist. Previously R&D manager for interventional oncology devices at Terumo Europe, and a senior scientist at UMC Utrecht and TU Delft, after doctoral research at CNRS in Strasbourg.

Ewelina Skiba
Ewelina Skiba
Head of Finance

Previously financial controller at Pacmed and senior accountant at OLX Group, after finance roles at Colgate-Palmolive and the Royal Bank of Scotland.

Board of Directors

Emanuele Ostuni
Emanuele Ostuni
Board Member

Founding chief executive of ARTBIO, an alpha radioligand therapy company, from 2022 to 2026. Previously Head of Europe, Cell and Gene Therapy at Novartis Oncology, and in senior strategy and commercial roles at Sandoz, after co-founding Nano Terra and consulting at McKinsey & Company. Doctoral research at Harvard University.

Board Member
To be announced
Board Member
To be announced
Board Member
To be announced

Nijmegen

Aurelius is based on the Radboud campus in Nijmegen.

The Department of Radiology and Nuclear Medicine at Radboudumc has developed and manufactured radiotracers for clinical use for several decades, and has radiochemistry, preclinical imaging, and clinical nuclear medicine within one institution. The company works with the department from preclinical evaluation through to clinical studies.

Company
Aurelius Therapeutics B.V.
Address
Toernooiveld 300
6525 EC Nijmegen
The Netherlands
Registration
Chamber of Commerce (KvK) 93277946
Incorporated
2024